N – Hydroxy Phthalimide

Description :

N – Hydroxy Phthalimide  is the N-hydroxy derivative of phthalimide. The compound can be utilized as a catalyst for oxidation reactions, in particular for the selective oxidation (e. g. alkanes to alcohols) with molecular oxygen under mild conditions.
IUPAC Name: 1-Hydroxyphthalimide
Structure: NHPI features a phthalimide structure with a hydroxyl group (-OH) attached to the nitrogen atom of the imide group. The structure can be depicted as:
 
Physical State: White to off-white solid
Melting Point: Approximately 147-150°C
Solubility: Soluble in organic solvents such as dichloromethane, acetone, and ethyl acetate; generally insoluble in water.
Pharmaceutical Industry: Employed in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs), where precise oxidation reactions are crucial.
Agrochemical Industry: Useful in the production of agrochemicals and other specialty chemicals that require controlled oxidation steps.
N-Hydroxyphthalimide is a versatile chemical compound with significant utility in organic synthesis, especially in selective oxidation reactions. Its role as a catalyst makes it a valuable tool in both academic research and industrial applications.