Itraconazole

Description :

Sihauli Chemical sourcing supplying API, Active pharmaceutical ingredients intermediates, global generics, Pharma Raw Materials, industrial & Specialty Chemicals. our offices at USA, UK, CANADA, AUSTRALIA. generics, Pharma Raw Materials.

• Chemical Formula: C35H38Cl2N8O4
• Molecular Weight: 705.61 g/mol
• IUPAC Name: (2S,4S)-4-(4-chlorophenyl)-2-[4-(2,4-dichlorophenyl)-2,3-dihydro-1H-pyrazol-1-yl]-1,3-thiazole
• Enzyme Inhibition: It inhibits the enzyme lanosterol 14α-demethylase, which is essential for converting lanosterol to ergosterol.
• Effect: This inhibition disrupts the synthesis of ergosterol, weakening the fungal cell membrane and leading to cell death or growth inhibition.
• Hypersensitivity: Avoid use in patients with known hypersensitivity to itraconazole or other azole antifungals.
• Heart Failure: Caution or avoid use in patients with a history of heart failure or reduced ejection fraction.