Atazanavir Sulphate

Description :

Applications
Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV).
Description
Atazanavir Sulfate is a sulfate salt form of atazanavir, an aza-dipeptide analogue with a bis-aryl substituent on the (hydroxethyl)hydrazine moiety with activity against both wild type and mutant forms of HIV protease. Atazanavir does not elevate serum lipids, a common problem with other protease inhibitors.
Preparation
According to an aspect of the present invention, there is provided a process for the preparation of Compound (A) that comprises preparing atazanavir sulphate by treating atazanavir base (Compound (II)) with sulphuric acid in a combination of solvents, and isolating Compound (A).
Chemical Properties
Atazanavir sulfate is a white to pale yellow crystalline powder with low solubility in water, known for its antiviral properties, and is a vital component in the treatment of HIV infection.
Definition
Atazanavir sulfate is a sulfated derivative of atazanavir, a protease inhibitor used in the treatment of HIV/AIDS by inhibiting the HIV protease enzyme.