Amitriptyline

Description :

Applications
Amitriptyline is used to treat symptoms of depression. Amitriptyline is in a class of medications called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance
Description
Amitriptyline is used to treat symptoms of depression. It works on the central nervous system (CNS) to increase levels of certain chemicals in the brain. This medicine is a tricyclic antidepressant (TCA).
Preparation
Amitriptyline (7.1. 4) is synthesized by interaction of 10,11-dihydro-N,N-dimethyl-5H-dibenzo[a,d]cyclohepten-5-one with 3-dimethylaminopropylmagnesium bromide and the subsequent dehydration of the resulting tertiary alcohol (7.1. 3) using hydrochloric acid [6–11].
Chemical Properties
Amitriptyline is a highly lipophilic molecule having an octanol-water partition coefficient (pH 7.4) of 3.0, while the log P of the free base was reported as 4.92. Solubility of the free base amitriptyline in water is 14 mg/L.
Definition
Amitriptyline is a tricyclic antidepressant medication used to treat various mental health conditions, primarily depression and neuropathic pain.