Abacavir Sulfate

Description :

Applications
Abacavir is an antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV. Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.
Description
Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring.
Preparation
Stage-1 : N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide is reacted with (1S,4R)- 4-Amino-2-cyclopentene-1- methanol Tartrate, Sodium Carbonate in presence of Isopropyl Alcohol solvent media to get Stage-1 Compound.
Chemical Properties
Abacavir sulfate is a white crystalline powder with high solubility in water, known for its antiviral properties, targeting HIV reverse transcriptase, and often used in pharmaceutical formulations.
Definition
Abacavir sulfate is a pharmaceutical compound used in the treatment of HIV/AIDS, inhibiting the reverse transcriptase enzyme critical for viral replication.