Trifluoroacetic Acid Anhydride

Description :

It is also used in the oxidation of aldehydes to acids, esters, amides as well as in the protection of alcohols and amines. In addition, it is used as analytical reagents, solvents and dehydration condensing agent. It serves as an intermediate of fluorine fine chemicals, pharmaceuticals and agrochemicals.
Chemical Formula: C4H3F6O3\text{C}_4\text{H}_3\text{F}_6\text{O}_3C4​H3​F6​O3​
Molecular Weight: Approximately 186.07 g/mol
Anhydride Group: The molecule consists of two trifluoroacetyl groups (CF3CO\text{CF}_3\text{CO}CF3​CO) linked by an oxygen atom, forming an anhydride.
Appearance: A colorless to pale yellow liquid.
Boiling Point: Approximately 56-58°C.
Melting Point: Typically around -32°C.
Solubility: Soluble in organic solvents like dichloromethane and acetonitrile but generally not miscible with water.
Dehydration of Trifluoroacetic Acid: The most common method involves the dehydration of trifluoroacetic acid using a dehydrating agent like acyl chloride or phosphorus pentoxide (P₂O₅). The reaction typically produces trifluoroacetic acid anhydride and water.
Fluorine Chemistry: In the synthesis of fluorinated pharmaceuticals and agrochemicals. The trifluoroacetyl group is a useful functional group in drug design due to its electron-withdrawing properties.